OEB (Occupational Exposure Band) is a classification system that categorizes substances based on their toxicity and hazard potential due to exposure. Typically the scale ranges from OEB 1 (least hazardous) to OEB 5 (most hazardous). OEB bands are typically defined in terms of OEL (Occupational Exposure Levels). OEB bands are not standardised. The OEL for each OEB band are defined by individual organisations. For example OEB 5 might be defined as an OEL range of 0.1-1 ug/m³; OEB 4 could correspond to an OEL range of 1-10 ug/m³. Further Organizations specify containment measures for different OEB bands. OEB 5 substances require maximum containment (e.g., Isolators, RABS, Glove boxes, Closed Systems, HEPA filters on exhaust air). OEB 1 substances have lower containment requirements (e.g., localized containment with point exhaust systems, Gowning control and PPEs, air showers).
OEL (Occupational Exposure Level) represents the permissible maximum concentration of a substance to which a person may be exposed during work. It is usually expressed in micrograms per cubic meter (ug/m³) or milligrams per cubic meter (mg/m³). OEL values are derived from toxicity data and are more standardized. Different organizations (such as OSHA and IFA) publish OEL levels for various substances. Or it may be derived by toxicology experts based on available toxicity data (when published OEL information is not readily available). There are professional agencies like Affigility, ToxHub who provide expert services for determination of OEL values for Pharmaceutical Substances
OEB (Occupational Exposure Band) is a classification system that categorizes substances based on their toxicity and hazard potential due to exposure. Typically the scale ranges from OEB 1 (least hazardous) to OEB 5 (most hazardous). OEB bands are typically defined in terms of OEL (Occupational Exposure Levels). OEB bands are not standardised. The OEL for each OEB band are defined by individual organisations. For example OEB 5 might be defined as an OEL range of 0.1-1 ug/m³; OEB 4 could correspond to an OEL range of 1-10 ug/m³. Further Organizations specify containment measures for different OEB bands. OEB 5 substances require maximum containment (e.g., Isolators, RABS, Glove boxes, Closed Systems, HEPA filters on exhaust air). OEB 1 substances have lower containment requirements (e.g., localized containment with point exhaust systems, Gowning control and PPEs, air showers).
OEL (Occupational Exposure Level) represents the permissible maximum concentration of a substance to which a person may be exposed during work. It is usually expressed in micrograms per cubic meter (ug/m³) or milligrams per cubic meter (mg/m³). OEL values are derived from toxicity data and are more standardized. Different organizations (such as OSHA and IFA) publish OEL levels for various substances. Or it may be derived by toxicology experts based on available toxicity data (when published OEL information is not readily available). There are professional agencies like Affigility, ToxHub who provide expert services for determination of OEL values for Pharmaceutical Substances
Reference: ECA Difference between OEB and OEL (https://www.gmp-compliance.org/gmp-news/containment-what-is-the-difference-between-oeb-and-oel?utm_source=Newsletter&utm_medium=email&utm_campaign=NL-PEU_KW31)